Pharmacist Recommended Products for Mixed Cough and Cold
These products include combination of cough suppressants, expectorants, decongestants, fever and pain reducers and antihistamines. Some formulas are designed for people with high blood pressure. Kids have their specific formulas.
-
For daytime use, stick to non-drowsy formulas (DayQuil, Tylenol Daytime, or Amazon Day formulas) to stay alert while reducing cough, fever, and congestion.
-
For nighttime, NyQuil or other sedating options can help with rest but often cause drowsiness.
-
If you have high blood pressure or heart problems, Coricidin® is the safest choice since it avoids phenylephrine and pseudoephedrine.
-
For children, always use pediatric-labeled products like Dimetapp and follow dosing instructions carefully.
-
Combination products are convenient but may contain overlapping ingredients—check labels to avoid double dosing acetaminophen or dextromethorphan.
-
Chest rubs and humidifiers are very helpful in soothing the airway passages and help dissolve mucous.
-
Day & Night Combo Packages – Convenient co-packs that provide separate daytime (non-drowsy) and nighttime (sedating) options for round-the-clock relief. Common examples include: NyQuil & DayQuil Co-Pack, Tylenol® Day & Night Gelcaps, Tylenol® Day & Night Liquid, Amazon Day & Night Capsules, Amazon Day & Night Liquid.
​
Find on Amazon​
Tylenol day & night gel capsules Combo
Tylenol day & night liquid Combo
Day&night capsules-Amazon Brand Combo
Day&night liquid-Amazon Brand Combo
Humidifier for chest congestion
​Children’s Dimetapp® Cold & Cough
​​​​
Want to learn more, read the product description below.
​
NyQuil® Cold & Flu – Combination formula with acetaminophen for pain/fever, dextromethorphan for cough suppression, doxylamine (sedating antihistamine), and phenylephrine for nasal congestion. Best for nighttime use with dry cough and cold symptoms. Avoid in hypertension; may cause significant drowsiness.
​
Tylenol® Cold + Flu Severe – Contains acetaminophen, guaifenesin (expectorant), dextromethorphan, and phenylephrine. Useful for mixed cough and congestion. Avoid if you have high blood pressure.
​​
Robitussin CF Max® – Similar to Tylenol Cold + Flu Severe, combining acetaminophen, guaifenesin, dextromethorphan, and phenylephrine. Good for cough with chest congestion and nasal symptoms. Avoid in hypertension.
​
Coricidin® HBP Cold & Flu – Specially formulated without phenylephrine or pseudoephedrine, making it safer for people with high blood pressure, heart disease, or sensitivity to stimulants. Available in both day (non-drowsy) and night (sedating) versions.
​
Children’s Dimetapp® Cold & Cough – Formulated for kids 6+, with child-appropriate doses of dextromethorphan, guaifenesin, and antihistamines. Offers safe relief without exceeding pediatric guidelines. Daytime and nighttime formulas available.​​
​