Muscle & Joint Pain
Over the counter relief options
Is it muscle or joint pain, is the treament the same or different?
Muscle and joint pain is a common complaint affecting people of all ages, caused by factors such as overuse, injury, strenuous exercise, or chronic conditions like arthritis. It often presents as aching, stiffness, swelling, or tenderness in the muscles or joints, and may limit mobility or daily activities.
Acute muscle pain usually improves within a few days, but persistent or recurring joint pain may indicate an underlying condition that requires further attention.​
Management often includes a combination of rest, stretching, and supportive care, but over-the-counter relief for muscle and joint pain plays a key role. Oral NSAIDs such as ibuprofen or naproxen reduce both pain and inflammation, while acetaminophen provides effective relief for those who cannot take anti-inflammatory medications.
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Topical products, including gels, patches, and creams containing menthol, lidocaine, or diclofenac, deliver targeted pain relief directly to sore areas. When combined with heat or ice therapy, OTC options help many people return to activity and maintain mobility.​​ Learn more to make an informed choice.
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Pharmacist-recommended products​​
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Advil® (Ibuprofen 200 mg)
A non-steroidal anti-inflammatory drug (NSAID) that reduces pain, inflammation, and swelling. It is particularly effective for muscle strains, joint aches, and minor injuries related to overuse or exercise. For best tolerance, take with food. View on Amazon
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Aleve® (Naproxen 220 mg)
A long-acting NSAID that provides up to 12 hours of pain and inflammation relief. It is a good choice for chronic muscle soreness, arthritis, or persistent stiffness that requires longer, more stable coverage throughout the day.
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AleveX® Topical Pain Spray
A menthol-based topical spray that delivers fast cooling relief directly to sore muscles or joints. It is helpful for flare-ups of arthritis, muscle tightness, or localized pain, and offers fewer systemic side effects because it works on the surface rather than through the bloodstream.
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Tylenol® (Acetaminophen)
Relieves pain and reduces fever without affecting stomach lining or causing NSAID-related irritation. It is a suitable option for individuals who cannot take ibuprofen or naproxen and offers steady relief for muscle soreness, joint discomfort, or mild injuries.
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Goody’s Powders for Reconstitution
Goody’s Powders dissolve quickly for rapid absorption and fast pain relief. They are available in multiple formulations, including aspirin-free, caffeine-free, multi-symptom, and nighttime options, allowing users to choose a formula that fits their specific needs and sensitivities.
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Voltaren® Gel (Diclofenac 1%)
A topical NSAID that penetrates the skin to reduce inflammation at the site of pain. It is especially effective for arthritis-related joint pain in the hands, knees, or wrists. For best results, rub it in thoroughly and use consistently.
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Icy Hot® Pain Relief Cream
Icy Hot uses a combination of cooling and warming sensations to relax tight muscles, reduce stiffness, and ease joint discomfort. The “cool-then-warm” effect helps distract nerve pathways and increases blood flow to support recovery.
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Capsaicin Cream
Capsaicin, derived from chili peppers, reduces pain by decreasing substance P, a neurotransmitter involved in sending pain signals. It is effective for arthritis, nerve pain (neuropathy), and chronic discomfort, but must be used consistently over days to achieve full benefit.
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ThermaCare® Heat Wraps
Can provide up to 8 hours of steady, air-activated heat to relieve stiff or aching muscles. They increase blood flow, ease tension, and are helpful for back pain, menstrual cramps, and muscle tightness that benefits from deep warmth.
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Reusable Heat Therapy Pads
An electric or microwavable—deliver consistent warmth to soothe recurring soreness. Heat helps improve blood circulation, reduce muscle spasms, and relax tight tissues, making it ideal for chronic tension or post-exercise recovery.
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Tiger Balm® Ointment
Tiger Balm is an herbal ointment containing menthol and camphor to increase circulation and reduce stiffness. It offers warming relief for muscle tension, back pain, and joint soreness, and can be applied before or after activity.
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Magnesium glycinate
A highly absorbable form of magnesium that supports muscle relaxation, reduces cramps, and aids recovery after physical stress. It is gentler on the stomach than other magnesium types, making it suitable for regular use.
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For fast relief after activity or sudden soreness, ibuprofen is a reliable first-line choice—always take them with food.
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Naproxen used less frequently than Ibuprofen and can be used for longer treatment times.
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If you need a stomach-friendly alternative, Tylenol® Extra Strength works well but does not reduce inflammation.
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For arthritis or localized pain, try Voltaren® Gel, AleveX® Spray, or Icy Hot® for direct relief.
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Heat therapies like ThermaCare® wraps or reusable pads are especially helpful for stiffness and chronic discomfort.
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Capsaicin cream is best suited for ongoing nerve-related pain.
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Natural options such as Magnesium Glycinate may help reduce cramps and support long-term muscle health.
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