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 Pharmacist Recommended Products for Motion Sickness 

Motion sickness medications are typically antihistamines that help with motion symptoms, but there are slight variations in effect.

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  • Choose dimenhydrinate for shorter trips when you need quick relief.

  • Use meclizine for longer travel days or when you want less drowsiness.

  • Reserve diphenhydramine for bedtime travel since it causes significant sedation.

  • Take doses 30–60 minutes before travel for best results.

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​Dimenhydrinate (Dramamine® Original)

Meclizine (Bonine)® Less Drowsy)

Diphenhydramine (Benadryl®)

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Want to learn more, read the product description below.

 

Dimenhydrinate (Dramamine® Original) – A well-known antihistamine that helps prevent and treat nausea, dizziness, and vomiting. Works best when taken 30–60 minutes before travel but may cause drowsiness or blurred vision.

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Meclizine (Bonine®, Dramamine® Less Drowsy) – A longer-acting antihistamine that provides up to 24 hours of relief with less sedation than dimenhydrinate. Also useful for vertigo and balance-related nausea.

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Diphenhydramine (Benadryl®) – A first-generation antihistamine with a rapid onset, making it effective for last-minute use. Strong sedating effects make it better for nighttime or when sleep during travel is acceptable.

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You could also check out non-medicated solutions for Motion sickness.

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