Fast-Acting Antacids (Immediate Relief)

These neutralize stomach acid on contact and work within minutes, making them ideal for occasional symptoms.

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Tums® (Calcium Carbonate)

A chewable antacid that quickly neutralizes stomach acid, providing rapid relief within minutes for mild heartburn, acid indigestion, and sour stomach. It works locally in the stomach without affecting acid production long-term.

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Pharmacist Tips

• Best for occasional symptoms, especially after large meals or trigger foods.

• Not intended for frequent or chronic use.

• May cause constipation with regular use.

 

Rolaids® (Calcium Carbonate + Magnesium Hydroxide)

A combination antacid that neutralizes stomach acid quickly. The addition of magnesium helps balance calcium’s constipating effects and may provide more balanced digestive tolerance.

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Pharmacist Tips

• Useful for episodic heartburn.

• Lower risk of constipation compared to calcium-only products.

• Excessive use may cause diarrhea due to magnesium.

 

Mylanta® (Aluminum Hydroxide + Magnesium Hydroxide + Simethicone)

A liquid antacid that neutralizes acid while also addressing gas and bloating. Simethicone helps break up gas bubbles, making it helpful for pressure or fullness after meals.

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Pharmacist Tips

• A good option when heartburn is combined with gas or bloating.

• Shake well before use and measure doses carefully.

 

H2 Blockers (Short-Term Prevention & Relief)

These reduce the amount of acid the stomach produces and provide longer relief than antacids.

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Pepcid® (Famotidine)

An H2 blocker that reduces acid production and begins working within 30–60 minutes, providing relief for up to 12 hours. It reduces stomach acid content by reducing acid secretion into stomach.

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Pharmacist Tips

• Can be used for relief or prevention (before trigger meals).

• Suitable for mild to moderate, recurring heartburn.

• Works best when taken once or twice daily as directed.

• Seek medical advice if symptoms persist beyond 2 weeks.

 

Tagamet HB® (Cimetidine)

Another H2 blocker that reduces stomach acid and can be used for both prevention and treatment of heartburn. It reduces stomach acid content by reducing acid secretion into stomach.

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Pharmacist Tips

• More likely to have drug interactions than other H2 blockers.

• Consult a pharmacist if taking other medications.

• Works best when taken once or twice daily as directed.

• Useful for occasional to moderate symptoms.

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Proton Pump Inhibitors (PPIs – Long-Term Control)

These block acid production at its source and provide 24-hour relief, but require several days of consistent use for full effect.

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Prilosec OTC® (Omeprazole)

A proton pump inhibitor that reduces stomach acid at the source, providing all-day control when taken consistently. PPIs significantly reduce acid production and secretion which makes them the most effective option for severe cases.

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Pharmacist Tips

• Take once daily, 30–60 minutes before breakfast.

• Best for frequent heartburn (≥2 days/week).

• Not for immediate relief—may take 1–4 days to work fully.

• Avoid long-term use unless advised.

 

Prevacid 24HR® (Lansoprazole)

A PPI that provides consistent 24-hour acid suppression and helps prevent recurring symptoms. PPIs significantly reduce acid production and secretion which makes them the most effective option for severe cases.

 

Pharmacist Tips

• Take once daily before breakfast.

• Intended for frequent symptoms, not occasional use.

• May take several days for full benefit.

• Long-term use may affect vitamin and mineral absorption.

 

Nexium 24HR® (Esomeprazole)

A PPI that blocks the final step of acid production, providing sustained acid control with daily use. PPIs significantly reduce acid production and secretion which makes them the most effective option for severe cases.

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Pharmacist Tips

• Best for persistent or frequent heartburn.

• Requires daily use for several days to reach full effect.

• Not suitable for immediate symptom relief.

• Long-term use may impact nutrient absorption.